![]() Negative pressure wound therapy (NPWT) is one such modality, which can be used for the treatment of superficial wounds and the drainage of deep wounds, and can completely remove the necrotic tissue and secretions of wounds, stimulate granulation tissue production, reduce bacterial infection, and promote wound healing ( 4). With the development of new medical treatments, many new modalities have been gradually applied in the treatment of wounds under the guidance of cytohistology and biochemistry ( 3). Diabetic foot (DF) is a common diabetic complication caused by hyperglycemia, resulting the peripheral nerve and vascular lesions, producing a dry and irritated skin on the foot, and finally leading to the formation of ulcers, which do not heal for a long time and lower the quality of life of the patients ( 2). ![]() In recent years, with the increase in the incidence of diabetes, complications caused by diabetes have increased ( 1). Keywords: Negative pressure wound therapy diabetic foot (DF) ulcer safety meta-analysis However, the negative pressure value should be appropriately maintained and adjusted to avoid bleeding tendency of the wound when applying this new modality. The amputation rate of both groups showed no statistically significant (OR =0.33, 95% CI: 0.09 to 1.26, P=0.10) too.ĭiscussion: Negative pressure wound therapy can effectively accelerate wound healing, it is equally safe with general routine treatment. The rate of adverse events of both groups showed no significant difference (OR =0.49, 95% CI: 0.10 to 2.42, P=0.38). The granulation tissue formation time of the NPWT group was significantly less than the standard group. ![]() Combined analysis using the fixed effects model showed that the healing rate of the NPWT group was significantly lower than the standard group. Results: In this study, 363 articles were initially screened, and 9 literatures were finally included, involving a total of 943 patients. The software RevMan 5.4 was used for analysis to obtain a forest plot and funnel plot. The Cochrane Review Handbook was used to assess the bias of the literatures. Randomized controlled trials (RCTs) published after 2010 were searched with the keyword “vacuum-assisted closure therapy” OR “negative pressure wound therapy” OR “diabetic foot”. Methods: The databases of PubMed, Embase, Ovid, and Cochrane library were selected as search platforms. In this article we will investigate the efficacy and safety of it by literature search and meta-analysis. Policy of Dealing with Allegations of Research Misconductīackground: Negative pressure wound therapy (NPWT) is one of the new modality for the treatment of diabetic foot ulcers.Policy of Screening for Plagiarism Process.
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